Top Billed Cast

1. 

   Nagarjuna Akkineni

   Nageswar Rao / Seetharamudu / Bittu

2. 

   Nageshwara Rao Akkineni

   Chaitanya

3. 

   Naga Chaitanya Akkineni

   Nagarjuna / Radha Mohan

4. 

   Shriya Saran

   Rama Lakshmi / Anjali

5. 

   Samantha Ruth Prabhu

   Krishna Veni / Priya

6. 

   Brahmanandam

   Girish Karnad

7. 

   Ali Basha

   Leonardo DiCaprio

8. 

   Posani Krishna Murali

   Inspector Dharma

9. 

   Jayaprakash Reddy

   Home Minister J.P.

10. 

    Shankar Melkote

    Yashwanth Rayudu

11. 

    Saranya Ponvannan

    Seetharamudu's Mother

12. 

    Satya Krishnan

    Lecturer

13. 

    Tejaswi Madivada

    Divya

14. 

    M. S. Narayana

    Father Francis

15. 

    Duvvasi Mohan

    Home Minister's Assistant

16. 

    Gundu Sudarshan

    Marriage Broker

17. 

    Saptagiri

    Nagarjuna's Friend

18. 

    Krishnudu

    Doctor

19. 

    Srinivasa Reddy

    Car Broker

20. 

    Chalapathi Rao

    Merchant

21. 

    Amitabh Bachchan

    Pratap (Special Appearance)

22. 

    Amala Akkineni

    Dance Teacher (Special Appearance)

23. 

    Akhil Akkineni

    Akhil (Special Appearance)

24. 

    Neetu Chandra

    Air Hostess (Special Appearance)

25. 

    Raashii Khanna

    Prema (Special Appearance)

26. 

    Lavanya Tripathi

    Radha Mohan's Friend (Special Appearance)